Direct measurement of L-type Ca2+ window current in heart cells.
نویسندگان
چکیده
منابع مشابه
Direct measurement of L-type Ca2+ window current in heart cells.
The activation and inactivation relations of several ion channel currents overlap, suggesting the existence of a steady-state or "window" current. We studied L-type Ca2+ channel window current in single cardiac Purkinje cells using a voltage-clamp protocol by which channels were first inactivated nearly completely during a long-duration depolarizing step, and then the recovery of Ca2+ current w...
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Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-type Ca2+ "window" current. We used the on-cell, patch-clamp technique to stud...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1992
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.70.3.445